By Richard Knox
Two small clusters of drug resistance don't a public health crisis make. But experts worry they could signal the development of a Tamiflu-resistant pandemic virus with the ability to spread from person to person -- at least under certain circumstances.
Health officials are investigating two unrelated clusters of hospital patients -- four patients in North Carolina, five in Wales who've been infected with swine flu viruses resistant to the mainstay antiviral drug Tamiflu.
All of the involved patients reportedly had weakened immune systems. That may have enabled the pandemic virus to replicate in their systems more freely. If these immuno-compromised patients had been given Tamiflu, that combination of factors may have led the virus to develop a point mutation conferring resistance against the drug.
categories: Swine Flu (H1N1)



