Anne Hathaway plays Maggie, a patient with early-onset Parkinson's disease, who falls for Jaime, a Viagra drug rep played by Jake Gyllenhaal, in Love and Other Drugs. David James/20th Century Fox and Regency Enterprises hide caption

itoggle caption David James/20th Century Fox and Regency Enterprises

Hermione Granger (Emma Watson, left), Ron Weasley (Rupert Grint) and Harry Potter (Daniel Radcliffe) face their hardest task yet - finding the Horcruxes that give Lord Voldemort his immortality, while staying hidden from the dark wizard. Warner Bros. Pictures hide caption

itoggle caption Warner Bros. Pictures

Dude, Where's My Arm? James Franco plays Aron Ralston, a hiker who must escape from a trapped position in an isolated canyon. Chuck Zlotnick/Fox Searchlight Pictures hide caption

itoggle caption Chuck Zlotnick/Fox Searchlight Pictures

Together at last: In the last installment of Stieg Larsson's Millennium Trilogy, journalist Mikael Blomkvist (Michael Nyqvist, left) and cyber-avenger Lisbeth Salander (Noomi Rapace) barely share any screen time. Music Box Films hide caption

itoggle caption Music Box Films

Cecile de France plays Marie Lelay, a woman who publishes a book after nearly dying. She makes an unexpected connection with Matt Damon's George Lonegan, a psychic trying to stop communicating with the dead. Ken Regan/Warner Bros. Pictures hide caption

itoggle caption Ken Regan/Warner Bros. Pictures

Luke Evans and Gemma Arterton star in Tamara Drewe Peter Mountain/Sony Pictures Classics hide caption

itoggle caption Peter Mountain/Sony Pictures Classics

Eduardo Saverin, played by Andrew Garfield,  and Mark Zuckerberg (Jesse Eisenberg) were college buddies when they started Facebook, but the friendship collapsed under the pressures of business. Merrick Morton/Columbia Pictures hide caption

itoggle caption Merrick Morton/Columbia Pictures

Michael Douglas is back in his Oscar-winning role as Gordon Gekko, whose iconic "greed is good" mantra and daring corporate raids made him a rock star of financial titans. Barry Wetcher/20th Century Fox hide caption

itoggle caption Barry Wetcher/20th Century Fox

Henry Joost and Ariel Schulman help Nev Schulman create a true-to-life film about an online relationship. Rogue Pictures hide caption

itoggle caption Rogue Pictures

From The Ashes: Acting, says Joaquin Phoenix, is like being a puppet. And even when he's not in front of the camera, he tells documentarian Casey Affleck, he's still (and always) playing a character named "Joaquin Phoenix." Magnolia Pictures hide caption

itoggle caption Magnolia Pictures

In The American, George Clooney is an amoral hero who moves from country to country, sheds past lives, kills for money and crafts weapons. David Edelstein says Clooney is the "last guy I'd cast as an anonymous assassin." Giles Keyte/Focus Features hide caption

itoggle caption Giles Keyte/Focus Features

Arresting Developments: Michael Cera plays Scott Pilgrim, a down-and-out bass player who falls hard for the mysterious, magnetic Ramona Flowers (Mary Elizabeth Winstead) -- and then has to fight for her. Double Negative/Universal Pictures hide caption

itoggle caption Double Negative/Universal Pictures

Clued In: Will Ferrell (left) and Mark Wahlberg play a pair of cops who are thrust into action and must hit the streets in order to solve a case. Macall Polay/Columbia TriStar hide caption

itoggle caption Macall Polay/Columbia TriStar

While You Were Sleeping: Leonardo DiCaprio plunges into people's minds while they sleep in order to extract corporate secrets in Christopher Nolan's sci-fi flick Inception. Warner Bros hide caption

itoggle caption Warner Bros