Blake Mycoskie started and sold four businesses before age 30. But only in Argentina did he discover the idea he'd want to pursue long term. After seeing a shoe drive for children, he came up with TOMS — part shoe business, part philanthropy. Andrew Holder for NPR hide caption

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TOMS: Blake Mycoskie

Blake Mycoskie started and sold four businesses before age 30. But only in Argentina did he discover the idea he'd want to pursue long term. After seeing a shoe drive for children, he came up with TOMS — part shoe business, part philanthropy. PLUS in our postscript "How You Built That," how a long-haired Southern Californian, Chris Healy, co-founded The Longhairs and created special hair ties for guys.

TOMS: Blake Mycoskie

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In 1981, engineer Rod Canion left Texas Instruments and co-founded Compaq, which created the first IBM-compatible personal computer. This opened the door to an entire industry of PCs that could run the same software. PLUS in our postscript "How You Built That," how a frustrated renter Melanie Colón created an easier way to communicate between neighbors and apartment staff, called Apt App. Andrew Holder for NPR hide caption

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Compaq Computers: Rod Canion

In 1981, engineer Rod Canion left Texas Instruments and co-founded Compaq, which created the first IBM-compatible personal computer. This opened the door to an entire industry of PCs that could run the same software. PLUS in our postscript "How You Built That," how frustrated renter Melanie Colón created an easier way to communicate with noisy neighbors, called Apt App.

Compaq Computers: Rod Canion

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In 1978, college drop-out John Mackey scraped together $45,000 to open his first health food store, "Safer Way." A few years later he co-founded Whole Foods Market — and launched an organic food revolution that helped change the way Americans shop. PLUS in our postscript "How You Built That," how Kyle Ewing created waterproof paper through his company TerraSlate. Andrew Holder for NPR hide caption

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Whole Foods Market: John Mackey

In 1978, college drop-out John Mackey scraped together $45,000 to open his first health food store, "Safer Way." A few years later he co-founded Whole Foods Market — and launched an organic food revolution that helped change the way Americans shop. PLUS in our postscript "How You Built That," how Kyle Ewing created waterproof paper through his company TerraSlate.

Whole Foods Market: John Mackey

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In 1972, Maureen and Tony Wheeler bought a beat-up car and drove from London "as far east as we could go." They wound up in Australia, by way of Afghanistan, India and Thailand. Their scribbled notes on how to travel on a shoestring became a book, which grew into Lonely Planet — the largest travel guide publisher in the world. Andrew Holder for NPR hide caption

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Lonely Planet: Maureen & Tony Wheeler

In 1972, Maureen and Tony Wheeler bought a beat-up car and drove from London "as far east as we could go." They wound up in Australia, by way of Afghanistan, India and Thailand. Their notes on how to travel on a shoestring became a book, which grew into Lonely Planet — the largest travel guide publisher in the world. PLUS in our postscript "How You Built That," how 15-year-old Michael Mendicino, with help from his mom, took a teenage trend and turned it into a board game called Bottle Flip.

Lonely Planet: Maureen & Tony Wheeler

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As a kid, Troy Carter dreamed of being a rapper, but soon discovered he was a better manager than a musician. He took Lady Gaga from obscurity to stardom – helping shape both her music and her brand. Then he turned his gift for spotting talent to spotting investment opportunities with his company Atom Factory. Andrew Holder for NPR hide caption

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Lady Gaga & Atom Factory: Troy Carter

As a kid, Troy Carter dreamed of being a rapper, but soon discovered he was a better manager than a musician. He took Lady Gaga from obscurity to stardom – helping shape both her music and her brand. Then he turned his gift for spotting talent to spotting investment opportunities with his company Atom Factory.

Lady Gaga & Atom Factory: Troy Carter

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Barbara Corcoran grew up in a poor Irish Catholic family in Jersey – with nine brothers and sisters. But she used her charisma to conquer the streets of Manhattan and build the real estate company, The Corcoran Group. She then reinvented herself as a shark – on Shark Tank. Andrew Holder for NPR hide caption

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Real Estate Mogul: Barbara Corcoran

Barbara Corcoran grew up in a working-class Irish Catholic family in Jersey – with nine brothers and sisters. But she used her charisma to conquer the streets of Manhattan and build the real estate company, The Corcoran Group. She then reinvented herself as a shark – on Shark Tank.

Real Estate Mogul: Barbara Corcoran

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Brian Scudamore didn't dream of a life hauling away other people's trash. But when he needed to pay for college, he bought a $700 pickup truck, painted his phone number on the side, and started hauling. Now 1-800-GOT-JUNK? makes over $200 million in annual revenue. Andrew Holder for NPR hide caption

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1-800-GOT-JUNK?: Brian Scudamore

Brian Scudamore didn't dream of a life hauling away other people's trash. But when he needed to pay for college, he bought a $700 pickup truck, painted his phone number on the side, and started hauling. Now 1-800-GOT-JUNK? makes over $200 million in annual revenue.

1-800-GOT-JUNK?: Brian Scudamore

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App developer Apoorva Mehta almost gave up on being an entrepreneur until he figured out what he really wanted to do: find a hassle-free way to buy groceries. Five years after launch, the grocery delivery app Instacart is valued at three billion dollars. Andrew Holder for NPR hide caption

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Instacart: Apoorva Mehta

App developer Apoorva Mehta almost gave up on being an entrepreneur until he figured out what he really wanted to do: find a hassle-free way to buy groceries. Five years after launch, the grocery delivery app Instacart is valued at $3 billion.

Instacart: Apoorva Mehta

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When Steve Case started out in the tech business in the mid-80s, the idea of the internet — as we think of it today — didn't exist. But with AOL, Case saw an opportunity to connect millions of people, through chat rooms, news updates, and the iconic greeting, "You've Got Mail." Andrew Holder for NPR hide caption

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AOL: Steve Case

When Steve Case started out in the tech business in the mid-80s, the idea of the internet — as we think of it today — didn't exist. But with AOL, Case saw an opportunity to connect millions of people, through chat rooms, news updates, and the iconic greeting, "You've Got Mail."

AOL: Steve Case

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As a refugee growing up in Tel Aviv, Haim Saban remembers not having enough money to eat. As an adult, he hustled his way into the entertainment business, writing theme songs for classic cartoons like Inspector Gadget and Heathcliff. But producing the mega-hit Mighty Morphin Power Rangers put him on track to becoming a billionaire media titan. Andrew Holder for NPR hide caption

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Power Rangers: Haim Saban

As a refugee growing up in Tel Aviv, Haim Saban remembers not having enough money to eat. As an adult, he hustled his way into the entertainment business, writing theme songs for classic cartoons like Inspector Gadget and Heathcliff. But producing the mega-hit Mighty Morphin Power Rangers put him on track to becoming a billionaire media titan.

Power Rangers: Haim Saban

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Ever since she was a little girl playing dress-up in her aunt's closet, Kendra Scott loved fashion. Her first business was a hat shop, which she started at 19 – it failed. A few years later, she started a jewelry business out of her spare bedroom. Andrew Holder for NPR hide caption

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Kendra Scott: Kendra Scott

Ever since she was a little girl playing dress-up in her aunt's closet, Kendra Scott loved fashion. Her first business was a hat shop, which she started at 19 – it failed. A few years later, she started a jewelry business out of her spare bedroom. Today the company is reportedly valued at more than a billion dollars.

Kendra Scott: Kendra Scott

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After living as a monk in India and running a plastics company in Florida, Manoj Bhargava decided to launch something new: a one-shot energy drink in a bright, battery-shaped bottle. Today, 5-Hour ENERGY is one of the most recognizable energy drinks in the world. Andrew Holder for NPR hide caption

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5-Hour Energy: Manoj Bhargava

After living as a monk in India and running a plastics company in Florida, Manoj Bhargava decided to launch something new: a one-shot energy drink in a bright, battery-shaped bottle. Today, 5-Hour ENERGY is one of the most recognizable energy drinks in the world.

5-Hour Energy: Manoj Bhargava

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Mei Xu started making candles in her basement — using old Campbell's soup cans as molds. Andrew Holder for NPR hide caption

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Chesapeake Bay Candle: Mei Xu

Twenty-five years ago, when Mei Xu emigrated from China to the U.S., she loved going to Bloomingdale's to gaze at their housewares. She eventually started making candles in her basement with Campbell's Soup cans, an experiment that led to the multi-million dollar company Chesapeake Bay Candle.

Chesapeake Bay Candle: Mei Xu

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Before he turned 40, Nolan Bushnell founded two brands that permanently shaped the way Americans amuse themselves: the iconic video game system Atari, and the frenetic family restaurant Chuck E. Cheese's. Andrew Holder for NPR hide caption

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Atari & Chuck E. Cheese's: Nolan Bushnell

Before he turned 40, Nolan Bushnell founded two brands that permanently shaped the way Americans amuse themselves: the iconic video game system Atari, and the frenetic family restaurant Chuck E. Cheese's.

Atari & Chuck E. Cheese's: Nolan Bushnell

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In 1962, Gordon Segal — with his wife Carole — opened a scrappy Chicago shop called Crate & Barrel. That store turned into a housewares empire that has shaped the way Americans furnish their homes. Andrew Holder for NPR hide caption

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Crate & Barrel: Gordon Segal

In 1962, Gordon Segal — with his wife Carole — opened a scrappy Chicago shop called Crate & Barrel. That store turned into a housewares empire that has shaped the way Americans furnish their homes.

Crate & Barrel: Gordon Segal

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As founder and CEO of Beyond Meat, Ethan Brown believes he can turn peas and lentils into protein that tastes — and feels – exactly like beef and chicken. He says they're not quite there yet, but after 8 years in business, their products are sold in 11,000 stores nationwide. Andrew Holder for NPR hide caption

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Live Episode! Beyond Meat: Ethan Brown

As founder and CEO of Beyond Meat, Ethan Brown believes he can turn peas and lentils into protein that tastes — and feels – exactly like beef and chicken. He says they're not quite there yet, but after 8 years in business, their products are sold in 11,000 stores nationwide. Recorded live in Anaheim, CA.

Live Episode! Beyond Meat: Ethan Brown

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Lyft: John Zimmer

Ridesharing wasn't a thing 12 years ago when John Zimmer was in college. But a class on green cities got him thinking about the glut of underused cars on the road, and eventually led him to co-found Lyft, a company that has helped make ridesharing a way of life.

Lyft: John Zimmer

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For years, Kate & Andy Spade — the founders of Kate Spade NY — worked out of a tiny NYC apartment. Andrew Holder for NPR hide caption

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Kate Spade: Kate & Andy Spade

A 1991 conversation at a Mexican restaurant led Kate & Andy Spade to ask, "What's missing in designer handbags?" Kate's answer was a simple modern-shaped handbag that launched the iconic fashion brand: Kate Spade.

Kate Spade: Kate & Andy Spade

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Virgin: Richard Branson

Richard Branson took a record shop and built it into a label, a bank, an airline, space tourism, and 200 other businesses — all under the name Virgin. But the serial entrepreneur has also had his share of failures.

Virgin: Richard Branson

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Zappos: Tony Hsieh

Computer scientist Tony Hsieh made millions off the dot-com boom. But he didn't make his mark until he built Zappos — a customer service company that "happens to sell shoes." Now Zappos is worth over a billion dollars and known for its completely unorthodox management style.

Zappos: Tony Hsieh

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Honest Tea: Seth Goldman

In 1997, after going for a long run, Seth Goldman was frustrated with the sugar-filled drinks at the corner market. So he brewed up a beverage in his kitchen, and turned it into Honest Tea.

Honest Tea: Seth Goldman

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Alli Webb's Drybar focuses on being the best at one thing: blow-drying hair. Andrew Holder hide caption

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Drybar: Alli Webb

A decade ago, full-time mom Alli Webb noticed a gap in the beauty market: there was nowhere that just focused on blow-drying hair. Now with 70 locations, Drybar is testament to Webb's motto: Focus on one thing and be the best at it.

Drybar: Alli Webb

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Zumba: Beto Perez & Alberto Perlman

Zumba began as a mistake: aerobics teacher Beto Perez brought the wrong music to class, then improvised a dance routine to go with it. For his students, it was more fun than work — and it eventually grew into one of the biggest fitness brands in the world.

Zumba: Beto Perez & Alberto Perlman

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Warby Parker: Dave Gilboa & Neil Blumenthal

In 2008, it was nearly impossible to buy a fashionable, affordable pair of glasses online. That simple frustration inspired the idea behind Warby Parker – and disrupted the eyewear industry.

Warby Parker: Dave Gilboa & Neil Blumenthal

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