Volunteers search for needles and other drug paraphernalia along Church Street in Austin, Ind., in April. The region has recorded 142 new HIV cases since December, according to the state, in an outbreak tied to injected-opioid use. Seth Herald/Nurphoto/Corbis hide caption

itoggle caption Seth Herald/Nurphoto/Corbis

Fake medicines are a 21st-century scourge, but they've been around for a long time. This advertising trade card for snake oil was printed in New York City around 1880. Transcendental Graphics/Getty Images hide caption

itoggle caption Transcendental Graphics/Getty Images

Work partners Jon Chintanaroad (left) and Mike Prestano are all smiles now, but founding a tech startup together threatened their friendship — and their business. April Dembosky/KQED hide caption

itoggle caption April Dembosky/KQED