Traders gather on the floor of the New York Stock Exchange. Henry Ray Abrams/AP hide caption

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Zach Galifianakis stars as Bobby, a psychiatric patient and mentor to 16-year-old Craig (Keir Gilchrist) in It's Kind of a Funny Story. K.C. Bailey hide caption

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Steve Buscemi plays politician-gangster Nucky Thompson in HBO's Boardwalk Empire. Abbot Genser/HBO hide caption

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Sheldon Cooper — a character played by Jim Parsons in CBS's The Big Bang Theory has an IQ of 187 and several advanced degrees but often has trouble with social interactions with other people. CBS hide caption

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