Amy Landecker and Jeffrey Tambor are two of the stars of Transparent, in which Tambor's character comes out as transgender to her three adult children. Beth Dubber/Amazon Studios hide caption

itoggle caption Beth Dubber/Amazon Studios

The Cosby Show starred Bill Cosby and Phylicia Rashad as Cliff and Clair Huxtable, an upper-middle-class couple in New York. Tempestt Bledsoe, Malcolm-Jamal Warner, Lisa Bonet and Keshia Knight Pulliam played four of their five children. Frank Carroll/AP hide caption

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This human-scale lab rat cage is parked near a skate park in Denver, Colo., to make a point about the lack of science on marijuana. Richard Feldman Studio/Sukle Advertising and Design hide caption

itoggle caption Richard Feldman Studio/Sukle Advertising and Design

In Metástasis, Diego Trujillo (center) plays Walter Blanco, a chemistry teacher who sells crystal meth with his former student José Miguel Rosas, played by Roberto Urbina. Manuel Rodriguez/UniMás hide caption

itoggle caption Manuel Rodriguez/UniMás

Tim Heidecker (left) and Eric Wareheim, shown promoting their film Tim and Eric's Billion Dollar Movie, have been friends for two decades. Victoria Will/AP hide caption

itoggle caption Victoria Will/AP

Daily Show correspondent Michael Che will become the first black co-anchor of Saturday Night Live's Weekend Update. Paul Marotta/Courtesy of Michael Che hide caption

itoggle caption Paul Marotta/Courtesy of Michael Che

On Boardwalk Empire, Steve Buscemi's character, Nucky Thompson, is modeled after Enoch "Nucky" Johnson, the corrupt county treasurer of Atlantic City during the Prohibition years. The HBO show started its fifth and final season Sunday. Macall B. Polay/HBO hide caption

itoggle caption Macall B. Polay/HBO

Theodore Roosevelt, seen here in 1885, was haunted by the fact that his father didn't fight in the Civil War. Library of Congress Prints and Photographs Division/PBS hide caption

itoggle caption Library of Congress Prints and Photographs Division/PBS