Otolaryngologist Sandra Lin uses under-the-tongue drops to treat patients with allergies at Johns Hopkins in Baltimore. Courtesy of Keith Weller/Johns Hopkins Medicine hide caption toggle caption Courtesy of Keith Weller/Johns Hopkins Medicine Shots - Health News Allergy Drops Under The Tongue May Be Fine Alternative To Shots March 27, 2013 Drops under the tongue to treat allergies sounds a lot nicer than allergy shots. A new review in JAMA says they're moderately effective, and relatively safe. But they're also not FDA-approved. Still, doctors, including an author of the study, are prescribing them off-label.