Travelers crowd around a ticketing counter at John F. Kennedy International Airport in April 2010 in New York. Jason DeCrow/AP hide caption toggle caption Jason DeCrow/AP Shots - Health News Epidemics Prefer Changing Planes In JFK Over ATL July 25, 2012 Researchers at MIT have developed a pretty nifty computer model to figure out the most influential U.S. airports in the early stages of an epidemic's spread. John F. Kennedy International is No. 1, followed by Los Angeles International. You might be surprised to learn that Honolulu's airport ranks third.