Experimental medicines related to ketamine, an anesthetic and club drug, are making progress in clinical tests. Wikipedia hide caption

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Antidepressant use nationally fell by 31 percent among adolescents between 2000 and 2010. Suicide attempts increased by almost 22 percent. JustinLing/Flickr hide caption

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Talk therapy is best for some people; antidepressants are better for others. Scientists say PET scans might help figure out early on what treatment a person needs. iStockphoto.com hide caption

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Researchers tested the antidepressant Lexapro, or escitalopram generically, to see if it would protect the heart against mental stress. Joe Raedle/Getty Images hide caption

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Chris Stephens, 28, who has been battling depression all of his life, plays with his dogs at home in Concord, Calif., on Friday. After a dose of ketamine, Stephens says, "I actually wanted to do things. I wanted to live life." Lianne Milton for NPR hide caption

itoggle caption Lianne Milton for NPR

The antidepressant Prozac selectively targets the chemical serotonin. Paul S. Howell/Getty Images hide caption

itoggle caption Paul S. Howell/Getty Images