Maria Fabrizio for NPR

Sarah Silverman plays a profoundly depressed woman who has gone off her medication in the film I Smile Back. Broad Green Pictures hide caption

toggle caption Broad Green Pictures
Katherine Streeter for NPR
Trina Dalziel/Ikon Images/Corbis
Stefano Bianchetti/Corbis

After watching a sad video clip, students in the study were less able to accurately identify the colors in a blue and yellow spectrum. Christopher Thorstenson/Open Science Framework hide caption

toggle caption Christopher Thorstenson/Open Science Framework

Experimental medicines related to ketamine, an anesthetic and club drug, are making progress in clinical tests. Wikipedia hide caption

toggle caption Wikipedia

About twice a year, statistics suggest, a pilot somewhere in the world — usually flying alone — deliberately crashes a plane. The Germanwing flight downed last week may be one such case. But most people who fit the psychological profile of the pilots in these very rare events never have problems while flying. Patrik Stollarz/AFP/Getty Images hide caption

toggle caption Patrik Stollarz/AFP/Getty Images

NPR thanks our sponsors

Become an NPR sponsor