A rat neuron before (top) and after (bottom) ketamine treatment. The increased number of orange nodes are restored connections in the rat's brain. Ronald Duman/Yale University hide caption

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Ketamine Relieves Depression By Restoring Brain Connections

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Chris Stephens, 28, who has been battling depression all of his life, plays with his dogs at home in Concord, Calif., on Friday. After a dose of ketamine, Stephens says, "I actually wanted to do things. I wanted to live life." Lianne Milton for NPR hide caption

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'I Wanted To Live': New Depression Drugs Offer Hope For Toughest Cases

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Ketamine has been used as an anesthetic for decades. It's also a widely popular but illegal club drug known as "Special K." When administered in low doses, patients report a rapid reduction in depression symptoms. Huw Golledge/flickr hide caption

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Could A Club Drug Offer 'Almost Immediate' Relief From Depression?

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The antidepressant Prozac selectively targets the chemical serotonin. Paul S. Howell/Getty Images hide caption

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When It Comes To Depression, Serotonin Isn't The Whole Story

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