Stung by a Portuguese man-of-war? Try vinegar or hot water to reduce the pain. Towle Neu/Flickr hide caption itoggle caption Towle Neu/Flickr Shots - Health News Taking The Sting Out Of Jellyfish Isn't Easy June 8, 2012 Your best bets? Carefully remove the tentacles and their stinging cells stuck in your skin. Then wash with hot water, or use saltwater if you're away from a bathroom or shower.