If hiking in the High Sierra gives you a headache, ibuprofen could help. Miguel Vieira/Flickr hide caption itoggle caption Miguel Vieira/Flickr Shots - Health News High Altitude Got You Down? Try Ibuprofen March 21, 2012 People sometimes take prescription drugs to keep from getting sick at high altitudes. But medical researchers wondered whether ibuprofen, the painkilling mainstay, would be an effective over-the-counter alternative. The results look promising.