Sales of prescription opioid painkillers have quadrupled since 1999, according to the Centers for Disease Control and Prevention. Rich Pedroncelli/AP hide caption

itoggle caption Rich Pedroncelli/AP

Bryan McDonel and his father, Mike, both served multiple tours in Iraq with the National Guard. Bryan was first prescribed painkillers before his deployment, and his dependence on medication prompted a downward spiral. Quil Lawrence/NPR hide caption

itoggle caption Quil Lawrence/NPR