A young boy talks with Tina Cloer, director of the Children's Bureau, in Indianapolis. The nonprofit shelter takes in children from the state's Department of Child Services when a suitable foster family can't be found. Cloer says the average length of stay at the shelter has increased from two days to 10 in 2015. Jake Harper/Side Effects Public Media hide caption

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Sales of prescription opioid painkillers have quadrupled since 1999, according to the Centers for Disease Control and Prevention. Rich Pedroncelli/AP hide caption

toggle caption Rich Pedroncelli/AP

Bryan McDonel and his father, Mike, both served multiple tours in Iraq with the National Guard. Bryan was first prescribed painkillers before his deployment, and his dependence on medication prompted a downward spiral. Quil Lawrence/NPR hide caption

toggle caption Quil Lawrence/NPR