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STEVE INSKEEP, host:

It's MORNING EDITION from NPR News. I'm Steve Inskeep.

RENEE MONTAGNE, host:

And I'm Renee Montagne.

In Your Health, we look at swine flu. The first H1N1 vaccination will be given to the public this morning. Officials in Indiana and Tennessee say health workers there will get the nasal spray version of the vaccine. And millions of doses are headed to clinics, schools and offices nationwide.

We ask you to send us questions. Some of you asked where to get the vaccine. Others are wondering if they should get it.

STEVE INSKEEP: We're going to get some answers this morning from two of our science correspondents and a few other experts. And we begin with NPR's Joanne Silberner who's on the line. Joanne, where are you?

JOANNE SILBERNER: I am at the Centers for Disease Control and Prevention. They have something called the Emergency Operation Center, where they take an information on swine flu outbreaks and vaccine availability. And pretty much everything on swine flu is being collected and analyzed here in front of me. There's a dozen screens with maps. They've really drilled for this and they're taking this in stride,

INSKEEP: So if you can't answer a question sitting where you are, we should be very, very afraid, pretty much.

SILBERNER: Well, I have people here to help me answer questions. How's that?

INSKEEP: Well let's go through a couple. We'll start with our first question from Lisa K. - last initial, K. - of Malvern, Pennsylvania. She writes: The swine flu shot will not be offered by my family doctor. How exactly will this work and where can I get my shot? So, how will it work?

SILBERNER: Well, it's being run by the government. The government has already purchased essentially all the vaccine being made. And the states goes to the CDC to order it and each state gets a percentage of what's available based on how many people live in that state. Then it goes from the distributor directly to school districts, clinics, hospitals, pharmacies, about 90,000 places across the United States.

And last week, millions of vaccines went on their way to the distribution centers and to the states, and that includes both the regular injectable vaccine and a new nasal spray version that's based on one that's already used for seasonal flu.

INSKEEP: So that's the first part of her question, how will this work, and then her next part is where do I get my shot?

SILBERNER: Well, in Lisa's case, she - her doctor could apply to the state and get vaccine from the state, or she can call up her state health department, the Pennsylvania Department of Health, by its Web site or phone in. I think that's going to be true of most states.

INSKEEP: We've also got questions from listeners who've written in with very specific questions about safety, Joanne. And we're going to get to those specific questions in a moment. But for right now, I just want to ask are some of the people on those computer screens that you're looking at monitoring safety issues?

SILBERNER: Yes. They're monitoring everything there is about this infection. And one of the people who's considering all the information that's being gathered is sitting right next to me, and her name is Dr. Beth Bell. She's with the National Center for Immunization and Respiratory Diseases at the CDC. And I'm just going to hand her off to you.

Dr. BETH BELL (Associate Director for Science, National Center for Immunization and Respiratory Diseases, CDC): Hi, Steve.

INSKEEP: Hi, Dr. Bell. How are you today?

Dr. BELL: Fine. How are you?

INSKEEP: Doing fine. Thanks for taking the time to speak with us here. I'd like to know how you think you're going to know if this vaccine starts to become a problem as you distribute it to those 90,000 sights across the country.

Dr. BELL: We're working very hard to make sure that we can closely monitor for adverse events once the vaccine is distributed. For example, we're working with a number of managed care organizations to track any adverse events that occur in their populations very quickly and to decide whether it's something to be worried about or not.

INSKEEP: Are the side effects from the swine flu vaccine any different from the seasonal flu vaccine that many people get at the same time?

Dr. BELL: So far the side effects are actually very similar. People will get a sore arm sometimes; some people might feel a little bit tired, have a little bit of headache. The kinds of side effects that one can expect to have in sometimes with various kinds of vaccines.

INSKEEP: Dr. Bell, thanks very much. If you'd hand the phone back to Joanne Silberner, I'd appreciate it.

Dr. BELL: I certainly will.

SILBERNER: Hi, Steve.

INSKEEP: Just one other quick question. This emergency operation center that you're in the middle of, did they set this up just for the swine flu?

SILBERNER: Oh, no. This is a place that's opened 24/7. They deal with things like hurricane response, food-borne outbreaks, any other major public health event they can deal with it here.

INSKEEP: NPR's Joanne Silberner is at the Centers for Disease Control, the Emergency Operation Center there. And we're going to hear next from NPR's Rickard Knox, who is monitoring developments from our studios here. Richard, good morning.

RICHARD KNOX: Good morning.

INSKEEP: He's our health and science correspondent. And how widespread are the safety concerns about this vaccine?

KNOX: There seems to be a lot of worries out there. There was a poll the other day from the magazine Consumer Reports that found that two-thirds of parents are saying that they are either holding off on getting their kids vaccinated or they've decided not to have their kids vaccinated. Their main concern is that they think the vaccine may not have been tested well enough.

INSKEEP: Let's listen to one of the questions that people have sent in.

Dr. IAN ZLATKIS (Pediatrician, New Orleans): Was it subjected to the same testing as the regular seasonal flu vaccine or were shortcuts taken as it was rushed to market?

INSKEEP: This gentlemen is identified as Dr. Ian Zlatkis, somebody who has questions himself even though he is a doctor.

KNOX: That's right. I think he's not alone out there. And for the answer to that, I'd like to go to Dr. Anthony Fauci. He's the director of the National Institute of Allergies and Infectious Diseases.

Dr. ANTHONY FAUCI (Director of the National Institute of Allergies and Infectious Diseases): The H1N1 pandemic flu vaccine is made exactly the same way with the same processing, with the same materials, as we make seasonal flu vaccine, which has an extraordinarily good safety record.

KNOX: He makes another point. He says the new vaccine really shouldn't be considered a new vaccine, a brand-new vaccine at all. It's like what they do every year with ordinary flu vaccines; they make little changes, they tweak it, they call them strain changes. It's just that this is a very big strain change.

INSKEEP: We had a question also from Erin Bolton(ph) of Baltimore, and she's in a group of people that has been strongly urged to get this vaccination. She writes: I'm pregnant. My baby is due in December. I'm planning to get vaccinated, she writes, but she's concerned that results of vaccine studies in pregnant women aren't in yet and she wonders whether she should wait.

KNOX: I put Erin Bolton's question to Dr. Frank Witter. He's at Johns Hopkins Medical School in Baltimore, and he's an expert in maternal fetal medicine.

Dr. FRANK WITTER (Johns Hopkins University, School of Medicine, Baltimore): Erin, you should take the flu vaccine. Not only should you take the seasonal flu vaccine, but you should also take the pandemic flu vaccine. Pregnant women have gotten very, very sick from this new virus and have actually died. So you should take the vaccine.

INSKEEP: Strong warning there, Richard Knox, but this is something that a lot of women may be reluctant to do when they're pregnant.

KNOX: I think a lot of pregnant women are very reluctant to take anything. But we already know that pregnant women are much more likely to get swine flu. If they get it, they're like six times more likely to die from it and that's really what Dr. Witter is emphasizing. A lot of his obstetrically colleagues worry that if they urge a woman to get vaccinated then she happens to miscarry, it may have nothing to do with the vaccine because we have no evidence that the flu vaccines do cause women to miscarry, but they may blame it on the doctor.

He says: well, you know, if that happens, I'd rather be blamed for a miscarriage than see a woman die from a flu that I might have helped her prevent.

INSKEEP: We're taking listeners questions about swine flu, and here's another one from Meghan Guptill(ph) of Orinda, California. She writes: As a young person with asthma, I am in the group of people who are supposed to get the first round of the vaccine. But, apparently she is hesitating, Richard Knox.

KNOX: Yes. And by the way, people with asthma are a really big group. They're about - more than 20 million Americans have it. The reason Meghan is hesitating, I understand, is because she's wondering if she should get the first vaccine out of the bloc, which will be the nasal spray type. It's called FluMist. But people with asthma aren't supposed to get FluMist because it might touch off asthma attacks, so she's worried about getting swine flu while she's waiting for the regular vaccine to be available. Asthma experts are saying she should wait until she can get the regular flu shot, not FluMist.

INSKEEP: We've been hearing, Richard Knox, about people who are worried about the vaccine. But let's talk a little bit here about people who say they are not that worried about swine flu. They wonder if it's really not that serious.

KNOX: A lot of people have been asking that. I hear it all the time. For that answer, let's go back to Dr. Tony Fauci of the NIH. He's really the government's top flu specialist.

Dr. FAUCI: Although, for the most part, it is a relatively mild infection. In the younger individuals who are getting infected, there's a small percentage, but a disturbing percentage who go on to develop serious disease and even some deaths. About 30 percent of the deaths are in people who are otherwise young, vigorous and healthy. You rarely, rarely see that with seasonal influenza.

KNOX: You might ask the question the other way around really, wouldn't there be a lot of anger if the government had not developed this vaccine and a number of people, especially young healthy people had died?

INSKEEP: Richard, thanks very much.

KNOX: You're welcome.

INSKEEP: NPR's Richard Knox.

RENEE MONTAGNE, host:

And if you have more questions, we'll have an expert answer them in a live Web chat today at noon Eastern Time. Go to npr.org/health.

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MONTAGNE: It's MORNING EDITION from NPR News.

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