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The health care bill promises to change the landscape for a lot of American businesses. Insurance companies, drug makers, hospitals and medical equipment manufacturers all had a huge stake in the passage of the bill. Although many will now face higher taxes and more regulation, there's also a big upside: millions of new customers.

NPR's Jim Zarroli has more.

JIM ZARROLI: For more than a year, health care companies have closely watched the debate in Washington, trying to figure out what it might mean for the industry.

Dan Mendelson is CEO of Avalere Health, which advises companies about health care policy.

Mr. DAN MENDELSON (CEO, Avalere Health): There have been so many iterations of this, it's been hard to follow. I mean, the good news right now is that the die has been cast, and these companies can move on and try to plan strategy.

ZARROLI: Mendelson says for most companies, the bill approved Sunday night is neither very good nor very bad.

Mr. MENDELSON: Across each of the different segments, there are pieces that will be good and pieces that will be more challenging.

ZARROLI: On the plus side, the bill will bring as many as 30 million new, paying customers into the health care system. Many small businesses that don't now provide health care coverage will be required to do so, and they'll be given tax credits to make it easier. That has enormous implications for drug makers, hospitals, nursing-home companies, the companies that make defibrillators and artificial joints.

Jeffrey Kleintop, chief market strategist for LPL Financial, says a lot of these companies have been struggling to expand their customer base. Now, almost overnight, it's been done for them.

Mr. JEFFREY KLEINTOP (Chief Market Strategist, LPL Financial): Historically, the key for these industries really hasn't been pricing. A lot of these companies just don't make their money on jacking up prices each year. On average, their prices stay relatively flat. It's really all about volume.

ZARROLI: Kleintop notes that a huge percentage of prescriptions never get filled in the United States each year because patients can't afford them. Now they can. In fact, drug makers have a lot to gain from the bill.

Mr. EDWARD KAPLAN (Senior Vice President, The Segal Company): They're going to get a new - again, a new base of customers they don't have today, and a third party in the most part will be picking up the tab for brand drugs, and that will lead to a nice new source of revenue.

ZARROLI: That's Edward Kaplan of the Segal Company, a human resources consulting firm.

There is a downside for drug companies. They'll have to pay big fees, and there will be new restrictions on how much they can charge for their products. But on balance, they'll probably come out ahead, which is why the pharmaceutical industry was a supporter of the bill.

The picture is also mixed for insurance companies. Although President Obama and other Democrats railed against the insurance industry in the run-up to the vote, Kaplan says insurance companies will see some benefits from the bill.

Mr. KAPLAN: I think most of the insurance companies will see, you know, a 10 percent increase in potential market share without a lot excessive regulation.

ZARROLI: But there will be new regulations. Policies will be sold on state-supervised marketplaces called exchanges. And there will be restrictions on the premiums that insurers can charge, and new requirements that they accept customers with preexisting medical conditions. Insurers will face new excise taxes. But Kaplan believes insurance companies will be able to adjust over the long haul.

Mr. KAPLAN: The reality is these insurance companies have a, you know, have a way of understanding risk and measuring risk and passing on that risk to the market.

ZARROLI: But some insurance companies are likely to have a tougher time than others. Among those most affected are those in the Medicare Advantage program. Funding for the program will be cut, which could push up costs, making it less attractive to the senior citizens it serves.

But on balance, insurance companies, like the health care industry as a whole, have survived the health care bill in much better shape than they feared. Now they have to figure out how to adjust to the new world.

Jim Zarroli, NPR News, New York.

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