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The World Health Organization has released a new multi-year plan on how to finally eliminate polio. That disease used to cripple hundreds of thousands of children around the world every year. Now global health officials believe they're on the verge of wiping it out. NPR's Jason Beaubien reports on what they want to do next.

JASON BEAUBIEN, BYLINE: They're calling the new polio roadmap the endgame strategic plan, and endgame sums up where global health officials finally are with polio. In 2011, there were 650 polio cases reported worldwide. Last year, that number dropped down to 223. This year, there have been only 19.

The World Health Organization is leading a multi-billion dollar charge to make polio the second human disease - after smallpox - to be eliminated. Currently, polio remains only in remote parts of Afghanistan, Pakistan and Nigeria.

DR. WALTER ORENSTEIN: The last cases are the hardest.

BEAUBIEN: Dr. Walter Orenstein is a professor of medicine at Emory University in Atlanta. He's been involved in the polio eradication effort for years.

ORENSTEIN: Obviously, if they were easy, we would have gotten rid of those reservoirs a long time ago.

BEAUBIEN: Those reservoirs are inside human beings. The polio virus needs a human host to reproduce, survive and spread. The new endgame plan aims to deny polio access to those hosts through intensive vaccination campaigns. It also strengthens polio monitoring worldwide, incorporates polio vaccination as part of routine childhood immunizations, and secures international stockpiles of the vaccine in case the virus does somehow come back.

Dr. Orenstein at Emory says the period in between what appears to be the last human case and the end of polio is a precarious one.

ORENSTEIN: We've been burned. In 2010 Tajikistan, which had been free of polio for many years, had an introduction of polio from India and had 460 cases, a massive outbreak.

BEAUBIEN: Although polio only continues to make people sick in Afghanistan, Pakistan and Nigeria, the virus has shown its ability to migrate. Egypt hasn't recorded a single new case of polio paralysis since 2004, yet last December, health officials discovered live polio virus circulating in the Cairo sewage system.

ORENSTEIN: I think the information from Cairo points out that as long as we have reservoir countries, polio can travel. You can genetically type the polio viruses, and this genetically was traced to Pakistan.

BEAUBIEN: So the main goal right now is to focus on wiping out those reservoirs, while at the same time making sure polio doesn't pop back up somewhere else. India launched a massive campaign to eliminate polio in the late 1990s, and seems to have succeeded. There hasn't been a single case recorded in India in more than two years.

DEEPAK KAPUR: Of course, it's not over until it's over all over the world.

BEAUBIEN: Speaking from New Delhi, Deepak Kapur is the head of Rotary International's efforts to wipe out polio from India. He says there's a constant fear in India that polio could get re-imported and come roaring back.

KAPUR: We in India have been guilty of exporting polio virus to almost every part of the world. And by the same channels by which it went, the virus could well come back into India.

BEAUBIEN: Kapur and others involved in the polio endgame say one of the biggest challenges in the coming years is keeping people vigilant and focused until it's clear that polio is really, truly gone. Jason Beaubien, NPR News, Washington.

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