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Ketamine appears to restore faulty connections between brain cells, according to research performed in mice. Kevin Link/Science Source hide caption

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Kevin Link/Science Source

Ketamine May Relieve Depression By Repairing Damaged Brain Circuits

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Spravato, the brand name for esketamine, a newly approved option for treatment-resistant depression. Janssen Pharmaceutica hide caption

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Janssen Pharmaceutica

FDA Approves Esketamine Nasal Spray For Hard-To-Treat Depression

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These PET scans show the normal distribution of opioid receptors in the human brain. A new study suggests ketamine may activate these receptors, raising concern it could be addictive. Philippe Psaila/Science Source hide caption

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Philippe Psaila/Science Source
Maria Fabrizio for NPR

From Chaos To Calm: A Life Changed By Ketamine

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Ketamine For Severe Depression: 'How Do You Not Offer This Drug To People?'

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Stefano Bianchetti/Corbis

Club Drug Ketamine Gains Traction As A Treatment For Depression

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Experimental medicines related to ketamine, an anesthetic and club drug, are making progress in clinical tests. Wikipedia hide caption

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Wikipedia

Depression Treatments Inspired By Club Drug Move Ahead In Tests

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George McCann has been diagnosed with a subtype of bipolar disorder called the "fear of harm" profile, and finds that a prescribed dose of ketamine every few days alleviates his symptoms. Michael Rubenstein for NPR hide caption

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Michael Rubenstein for NPR

A rat neuron before (top) and after (bottom) ketamine treatment. The increased number of orange nodes are restored connections in the rat's brain. Ronald Duman/Yale University hide caption

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Ronald Duman/Yale University

Ketamine Relieves Depression By Restoring Brain Connections

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