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Antonio Rapuano got an infusion of a monoclonal antibody to treat his COVID in Albano, Italy in 2021. Such infusions have been effective treatments for COVID during the pandemic, but doctors are now finding that most monoclonal antibodies no longer work against new variants of SARS-CoV-2. Yara Nardi/Reuters hide caption

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Yara Nardi/Reuters

How monoclonal antibodies lost the fight with new COVID variants

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Treatments like monoclonal antibody infusions and antiviral pills can prevent a case of COVID-19 from becoming life-threatening. But many of the available drugs are not being used. Emily Elconin/Bloomberg via Getty Images hide caption

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Emily Elconin/Bloomberg via Getty Images

Paxlovid tablets are packaged at a Pfizer factory in Italy. Pfizer hide caption

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Pfizer

Feds' contract with Pfizer for Paxlovid has some surprises

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Evusheld is a treatment authorized for prevention of COVID-19 in people who are seriously immunocompromised or who have had serious adverse reactions to COVID-19 vaccines. Peter Bostrom/AstraZeneca hide caption

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Peter Bostrom/AstraZeneca

Hospitals use a lottery to allocate scarce COVID drugs for the immunocompromised

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Thomas Hansmann/Pfizer

The COVID antiviral drugs are here but they're scarce. Here's what to know

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Molnupiravir, an antiviral drug to treat mild to moderate COVID-19, is under consideration by the FDA for possible authorization. Merck hide caption

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Merck

New antiviral drugs are coming for COVID. Here's what you need to know

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Jennifer Minhas had been a nurse for years when she contracted COVID-19 in 2020. Since then, lingering symptoms — what's known as long-haul COVID-19 — made it impossible for her to work. For months, she and her doctors struggled to understand what was behind her fatigue and rapid heartbeat, among other symptoms. Tara Pixley for NPR hide caption

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Tara Pixley for NPR

Deaths from COVID-19 are often due to the immune system overreacting to the coronavirus. New drugs to suppress that reaction are showing promise, say researchers. Westend61/Getty Images hide caption

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Westend61/Getty Images

Drugs Targeting Immune Response To COVID-19 Show Promise

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Nurse Janet Gilleran prepares to treat COVID-19 patient Mike Mokler with bamlanivimab, a monoclonal antibody drug from Eli Lilly, at the Respiratory Infection Clinic of Tufts Medical Center in Boston on Dec. 31, 2020. Craig F. Walker/Boston Globe via Getty Images hide caption

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Craig F. Walker/Boston Globe via Getty Images

Doctors Encouraged By Antibody Treatments For COVID-19

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President Trump's team of medical specialists overseeing his care at Walter Reed National Military Medical center. He will still have access to round-the-clock care from the White House medical staff. Brendan Smialowski/AFP via Getty Images hide caption

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Brendan Smialowski/AFP via Getty Images

Convalescent serum or blood plasma from a recovered COVID-19 patients is being studied as a treatment for others with the disease. The FDA is holding off on giving it emergency use authorization. Arnulfo Franco/AP hide caption

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Arnulfo Franco/AP