Scientists Test 'Trust Hormone' For Autism Fight Some children with autism are already being treated with the hormone oxytocin, even though it's not an approved therapy. Though early studies are promising, health experts fear we don't know enough about the long-term side effects of taking the drug.
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Scientists Test 'Trust Hormone' For Autism Fight

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Scientists Test 'Trust Hormone' For Autism Fight

Scientists Test 'Trust Hormone' For Autism Fight

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Now let's talk about another potentially risky treatment that is showing up online. It is a hormone called oxytocin. And it's also marketed to parents of autistic children. Just to be clear, it has nothing to do with a better known narcotic, OxyContin. This is oxytocin.

The website say the treatment improves the social skills of autistic children. It is often advertised as the trust hormone or the cuddle hormone.

NPR's Jon Hamilton reports that it's becoming popular even though scientists are not sure whether it's a safe or effective treatment for children.

JON HAMILTON: It's no wonder parents have such high hopes for oxytocin. So do a lot of researchers, like Jennifer Bartz at Mount Sinai School of Medicine in New York.

Dr. JENNIFER BARTZ (Department of Psychiatry, Mount Sinai School of Medicine): I think it definitely has promise, you know, and that's why we're studying it.

HAMILTON: The body releases oxytocin to produce contractions during labor and lactation in nursing mothers, and doctors also give it to help with childbirth. A few years ago, researchers realized that oxytocin also affects the brain.

Bartz says a dose given in a nasal spray seems to promote feelings of trust and empathy and bonding in both men and women. These are often impaired in people with autism.

Dr. BARTZ: Autism is associated with deficits in social cognition and social functioning. People have thought, well, perhaps oxytocin might be a good treatment for those deficits in autism.

HAMILTON: So Bartz and others have been testing this idea. One study in her lab looked at people's ability to recognize emotions in others. She says people with autistic traits usually aren't as good at this as other people.

Dr. BARTZ: But on oxytocin, their performance was indistinguishable. So we were really excited about this because it really suggests that it might be especially helpful for this population.

HAMILTON: Might be but so far there are only a few small studies, and none with young children.

Sue Carter, a biologist at the Brain-Body Center at the University of Illinois, says that's not much to go on.

Dr. SUE CARTER (Biologist, Brain-Body Center, University of Illinois): If I had an autistic child, I would not try this because I wouldn't want my child to be one who we later discovered had been harmed in some way. At the moment, this is a very premature experiment and hasn't even been studied in kids.

HAMILTON: Oxytocin affects the part of the nervous system that controls things like heart rate, breathing and digestion. Prescription versions carry warnings about side effects, including bleeding and seizures. And Carter says that's just from short-term treatment with the hormone.

Dr. CARTER: The big problem here is that there isn't any research to speak of at all on the long-term effects of oxytocin, the effects of repeated treatments, at least in children.

HAMILTON: Carter says it's possible that long-term treatment could cause a child's body to produce less oxytocin of its own or become less responsive to the hormone.

Geraldine Dawson is chief science officer for the advocacy group Autism Speaks and a researcher at the University of North Carolina at Chapel Hill. She says there's a pressing need for rigorous scientific studies of the hormone.

Dr. GERALDINE DAWSON (Chief Science Officer, Autism Speaks): Some physicians are already administering oxytocin to children sometimes as young as two years of age. So it's very important that we good science behind that. Is it really effective? Which children is it most effective for? And importantly, are there any adverse effects?

HAMILTON: So Autism Speaks is funding a new study in which autistic children as young as three will receive oxytocin. But results are many months off.

Jon Hamilton, NPR News.

INSKEEP: And that's Your Health for this Monday morning.

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