Lab Findings Support Provocative Theory On Cancer 'Enemy' Within : Shots - Health News Three separate teams of scientists have shown that so-called cancer stem cells can be found in brain tumors and early forms of skin and colon cancer. Evidence has been mounting in recent years for the existence of these cells, which are believed to resist standard chemotherapy and fuel the growth of tumors and relapses.
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Lab Findings Support Provocative Theory On Cancer 'Enemy' Within

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Lab Findings Support Provocative Theory On Cancer 'Enemy' Within

Lab Findings Support Provocative Theory On Cancer 'Enemy' Within

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  • <iframe src="" width="100%" height="290" frameborder="0" scrolling="no" title="NPR embedded audio player">
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Now, to a provocative theory about cancer. It could explain why cancer patients suffer relapses. The theory says there is a special type of cancer cell hiding in the body, that can survive standard chemotherapy and radiation. NPR's Rob Stein has this story about new research that supports the theory.

ROB STEIN, BYLINE: Evidence has been mounting, in recent years, for the existence of an especially insidious kind of cancer cell. They're called cancer stem cells. These aren't the embryonic stem cells that have been getting so much attention in recent years. But like embryonic stem cells, they're also very immature cells with interesting powers.

Robert Weinberg is a cancer biologist at MIT. He says these cancer stem cells seem to act like seeds for tumors.

ROBERT WEINBERG: After a tumor is treated by many conventional forms of therapy, the non-stem cells in the cancer are wiped out. But the cancer stem cells may survive, and thereafter regenerate an entirely new tumor, leading to what one calls clinical relapse.

STEIN: These relapses are what doctors call recurrences, or metastases. They're often much harder to treat than the original tumors, and they're what eventually kills many cancer patients. But the existence of these cells has been highly controversial. The new experiment set out to answer some of these doubts. Luis Parada led one of the studies, at the University of Texas.

LUIS PARADA: This was the first example of examination of a spontaneously growing tumor in its normal site of development, where we were able to trace the existence of cancer stem cells.

STEIN: Parada and his colleagues performed a series of experiments. They used sophisticated genetic techniques to trace and analyze brain tumor cells in mice. Two other teams in Europe conducted similar studies, but this time with early forms of either skin cancer or colon cancer. All the research is being published this week in three papers, in the journals "Nature" and "Science."

PARADA: With these three studies, we can say that in fact, three different kinds of tumors adhere to the cancer stem cell hypothesis.

STEIN: Even though the studies were done in laboratory mice, Weinberg, Parada and others say there's no reason to think the findings don't apply to people as well. And if that's the case, the new research could lead to new ways to fight cancer.

PARADA: It means that we've identified the enemy, finally.

STEIN: The key to defeating this enemy may be a whole new class of drugs that specifically target these cancer stem cells. Here's Robert Weinberg at MIT again.

WEINBERG: Previously, we thought all we needed to do is kill off all the cells in the tumor, without having any recognition of the existence of these sub-populations of cancer stem cells. Now, we come to realize that both the non-stem cells, and the stem cells, need to be eliminated in the tumor in order for one to have a durable clinical response - which may eventually lead, actually, to a cure.

STEIN: But not everyone is convinced. Some scientists remain skeptical that what the researchers have found are really cancer stem cells. Scott Kern studies cancer genetics at Johns Hopkins. He says the new data falls far short of being conclusive.

SCOTT KERN: The main issue is, can you prove that these things exist? And that means considering the range of alternative explanations and disproving each one, one after another. And that's just not being done. I think that the field has not matured.

STEIN: Despite the skeptics, drug companies have already started designing drugs to target cancer stem cells. Max Wicha, of the University of Michigan, is testing some of them.

MAX WICHA: These three studies add further impetus to us moving ahead with these trials, to try to eliminate these cancer stem cells in the hope that it will improve the outcome for patients with a variety of different kinds of cancer.

STEIN: So scientists will continue to search for more conclusive evidence of the existence of these cancer stem cells, and look for new ways to kill them without harming the patients themselves. Rob Stein, NPR News.

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