Tests Of New Ebola Drugs Could Take Place As Early As November : Goats and Soda New drugs and vaccines can take years to develop. But health officials and researchers are accelerating tests of experimental drugs to fight the outbreak in West Africa.
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Tests Of New Ebola Drugs Could Take Place As Early As November

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Tests Of New Ebola Drugs Could Take Place As Early As November

Tests Of New Ebola Drugs Could Take Place As Early As November

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AUDIE CORNISH, HOST:

Health officials wanted to know if experimental drugs used by Americans could save other people from Ebola.

STEVE INSKEEP, HOST:

Early in west Africa's outbreak, several Americans who work there were flown home for treatment. That treatment included several experimental drugs, and the patients survived.

CORNISH: Now health officials are gearing up to test those same drugs and some experimental vaccines inside the countries worst hit by Ebola. They want to get clinical trials running within months; it's a process that usually takes years. NPR's Richard Harris reports.

RICHARD HARRIS, BYLINE: Researchers have been working methodically on vaccines that could protect people from the Ebola virus and drugs that could treat sick people. The research has been going on for many years, but Dr. Peter Horby at Oxford University says no product has made the leap from the laboratory to widespread human tests.

PETER HORBY: These drugs can only be tested properly during epidemics because that's the only time that we will have Ebola patients.

HARRIS: And with the current epidemic growing so rapidly, there's a sense of real urgency. So Horby has funding from Britain's Wellcome Trust to put at least a handful of experimental drugs to the test.

HORBY: What we would like to do is to enroll our first patients before the end of November. Now, that is a very ambitious timeline by clinical trial standards, but I think that has to be our aspiration.

HARRIS: Horby plans to run the tests at west African clinics set up by Doctors Without Borders, and he has a short list of possible drugs. It includes ZMapp, which has been tried in a handful of patients in this outbreak, and a potential drug made by a company called Tekmira, which was given to a medical worker with Ebola who was treated in Nebraska. A third candidate is called AVI-7537. Sarepta Therapeutics in Cambridge, Massachusetts, started to develop this drug in 2010 under a contract with the U.S. military.

MICHAEL WONG: The Ebola study got discontinued in late 2012 because of the fiscal budgetary issues in the United States at the time.

HARRIS: That's Dr. Michael Wong from Sarepta. Those early tests showed it appeared to be safe in a small sample of people and fairly effective in treating monkeys with Ebola, but the budget cut stopped further tests to develop the medication. And Wong says there's a little bit of that drug left over.

WONG: There's enough drug substance to treat up to 25 adult patients for a full course.

HARRIS: He says that should be enough for the initial tests in west Africa. And if those initial results are promising, the company has enough ingredients to make another 100 to 150 doses, but that's still a miniscule supply.

So could you get tens of thousands of doses in a matter of months, say?

WONG: That's the corporate goal.

HARRIS: But Wong says Sarepta is a small company that doesn't have the money to ramp up production right now just on speculation that the drug will end up working.

You'd think that some government agency would say, wow, you know, if this works, we want more yesterday, and they would be giving you money right now to ramp up your production.

WONG: Yeah, no, absolutely.

HARRIS: Sarepta is looking for that money, but it hasn't found a donor as yet. The government is paying the company that makes ZMapp to ramp up its production, and the supply lag is not such a big issue for potential vaccines. Pharmaceutical giant GlaxoSmithKline has been developing a vaccine to protect people from Ebola. Ripley Ballou from GSK Biologicals in Belgium says the company is gearing up to produce tens of thousands of doses of the vaccine even before they test it broadly in people.

RIPLEY BALLOU: We are doing extraordinary things to try to accelerate this development to the point where we can do something that would normally take us a year to a year-and-a-half in just a few months.

HARRIS: So when you say a couple of months, do you think you could have tens of thousands of doses by the end of this calendar year?

BALLOU: Well, that's our plan.

HARRIS: If the vaccine appears to be safe, they could start offering it to health care workers in west Africa since they are at highest risk of getting Ebola. The potential benefit to them would have to outweigh the risk of unexpected problems, which could result from the hurried testing. Dr. Peter Horby at Oxford says he still believes that public health measures - like finding and isolating people sick with Ebola - will have the biggest impact on stopping the epidemic.

HORBY: But at the same time, there are other things, like vaccines, like drugs, that can contribute to that. And we should be pursuing those actively as well because this is a huge humanitarian crisis.

HARRIS: The challenge is to move forward as quickly as possible while minimizing the risks that come with unproven drugs and vaccines. Richard Harris, NPR News.

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