STEVE INSKEEP, HOST:
In Your Health on this Monday, it's time to wake up and think about sleep. More than 50 million Americans, we're told, have a sleep disorder such as insomnia, restless leg syndrome or sleep apnea. And there's growing evidence that a lack of sleep can damage the body as well as the brain. NPR's Jon Hamilton reports.
JON HAMILTON, BYLINE: Nodding off is a bad idea if you're driving on the Massachusetts Turnpike, but Michael Arnott says sometimes he just couldn't help it.
MICHAEL ARNOTT: I would get groggy and feel like I've got to keep talking, open the window.
HAMILTON: Arnott's wife, Mary White, says her husband's drowsiness could be scary.
MARY WHITE: All of a sudden, there'd be a change in the speed and I'd look over and his eyes would be starting to close. And then I immediately - wake up.
HAMILTON: White thought her husband might have sleep apnea, which disrupts breathing, but Arnott, who is 67, thought of sleep apnea as something that affects people who are overweight or smoke or drink a lot.
ARNOTT: I'm a runner. I've run for more than 40 years. I used to do marathons. Now I just do five- and 10-kilometer road races.
HAMILTON: So his wife took the initiative.
WHITE: I asked him to see a doctor, and he wouldn't. And then when I saw a study that he could get paid for, then that was something that worked.
HAMILTON: The study was at Brigham and Women's Hospital in Boston, not too far from the couple's home in Cambridge. Arnott spent the night in the hospital's sleep lab and doctors found a couple of problems.
ARNOTT: I've got what they call moderate obstructive sleep apnea.
HAMILTON: Arnott also has restless leg syndrome and tends to kick during the night. Those disorders, along with his tendency to stay up late and wake up early, meant he wasn't getting enough high-quality sleep. And research in the past couple of decades shows that inadequate sleep can raise the risk of a car crash, heart disease, diabetes and perhaps even Alzheimer's. Some of that research was done in the same sleep lab at Brigham and Women's Hospital where Arnott spent the night.
CHARLES CZEISLER: This is the control room here.
HAMILTON: Charles Czeisler runs the hospital's division of sleep and circadian disorders.
CZEISLER: And you can see the brain wave recordings are being displayed from one of the participants. You also see a continuous recording of body temperature.
HAMILTON: The sleep lab includes rooms that completely isolate study participants from the outside world.
CZEISLER: You notice that there are actually two doors. So we have an anteroom. And now we're going to close this interior door. And you see how quiet it is in this room.
HAMILTON: In highly controlled environments like this one, Czeisler and other researchers have demonstrated that sleep can affect everything from blood pressure to memory to metabolism.
CZEISLER: One of the things that we've shown here in this facility is that within two and a half weeks, we can take someone who is young, healthy, fit and put them in a pre-diabetic state just by putting them on an irregular schedule.
HAMILTON: Czeisler says research has also revealed a strong connection between sleep and the immune system.
CZEISLER: People who are not getting enough sleep, if they're exposed to a virus like the adenovirus that causes the common cold, they will have a 200 to 300 percent increased risk of actually catching a cold.
HAMILTON: Lots of studies have found that a lack of sleep increases the risk of a heart attack or stroke. And Czeisler says new research is showing how sleep helps the brain stay healthy.
CZEISLER: It's during sleep that we clear out many of the toxins that build up during wakefulness. And those toxins include beta-amyloid, which can be damaging to neurons.
HAMILTON: Beta-amyloid is what forms the sticky plaques appear in the brains of people with Alzheimer's disease. Most sleep disorders can be treated, but often, they're not. Michael Arnott, the sleepy driver from Cambridge, didn't address his sleep apnea and restless leg syndrome until his wife intervened. Andrew Wellman, one of the Harvard doctors who has worked with Arnott, says that's typical.
ANDREW WELLMAN: My whole clinic is full of patients who are brought in by their spouses.
HAMILTON: Wellman says he asks these patients a simple question.
WELLMAN: What I always ask is, do your eyelids get heavy when you'd prefer to be awake? And that, to me, is a very specific symptom of sleepiness.
HAMILTON: As opposed to fatigue or tiredness, which don't necessarily indicate a sleep disorder. Wellman says many of his patients, like Arnott, have sleep apnea. It affects about 1 in 3 adult men and becomes more common with age. Wellman says the diagnosis is usually made by measuring the flow of air in and out of the lungs during sleep.
WELLMAN: If that flow is diminished, then that's the primary measurement that we use to detect these sleep apnea events.
HAMILTON: The problem can be in the brain, a condition called central apnea, but more often it's in the airway, which gets blocked during sleep. Wellman says Arnott has an unusual type of obstructive sleep apnea.
WELLMAN: His airway actually collapses at the epiglottis, which is a structure just below the base of the tongue that prevents food from going down in the airway.
HAMILTON: Regardless of the cause, the go-to treatment for sleep apnea is a continuous positive airway pressure device, often called a CPAP machine. Arnott tried one for several months and hated it.
ARNOTT: You have to have a mask on your face, you have a machine making noise all night, and you have to have electricity. We hike. We go to places in the White Mountains of New Hampshire and Maine where electricity is not always there.
HAMILTON: Wellman says he hears a lot of complaints like that.
WELLMAN: Somewhere around 50 percent of patients don't adhere to their therapy, and that's quite a lot of people. Probably there's many people that don't even come to the sleep lab 'cause they know that they might get that breathing machine and they don't want it.
HAMILTON: One alternative is surgery, another as an oral appliance that forces the lower jaw forward to help keep the airway open. That's what Arnott chose, and he's made other changes, too. He now sleeps on his side, which reduces apnea. He tries to get to bed at the same time each night and he has a new priestly routine.
ARNOTT: I found yoga. And doing it before bed or within an hour before bed really helps with the restless leg.
HAMILTON: Arnott says the changes have made a big difference. For instance, he no longer finds himself nodding off at church or at the wheel.
ARNOTT: There's times on long trips when Mary actually says, I'm getting groggy, you drive.
HAMILTON: Jon Hamilton, NPR News.
INSKEEP: And that's Your Health on this Monday morning.
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