AILSA CHANG, HOST:
Let's say you're a scientist and you've invented what you think is a useful treatment for pain, but you don't have the money to go through the regulatory approval process. Should you try to sell it to consumers anyway? That's the dilemma Ted Price and his colleagues faced. As part of his series on inventions, NPR's Joe Palca reports on what Price decided to do.
JOE PALCA, BYLINE: Ted Price is a researcher at the University of Texas, Dallas. His research focuses on solving a vexing problem about pain.
TED PRICE: Why pain persists even though injuries may heal.
PALCA: Price had experienced this himself, injuries from playing basketball that seemed to hurt long after the initial swelling and inflammation had gone away. To find the answer, Price and his colleagues focused on chemical signals sent inside nerve cells. They found that a lot of chemical pathways these signals used were activated inside nerves immediately after an injury, but just two pathways remained activated when pain persisted.
PRICE: We had this really great idea a long time ago - it was about 2009 - that we would inhibit one of these pathways and that would solve pain.
PALCA: There was just one small problem with this really great idea.
PRICE: We were completely wrong.
PALCA: Shutting down just one pathway had no effect on pain. But then they found a compound that seemed to shut down both pathways, acting like a kind of fire extinguisher to the persistent pain signals. Price says it was a natural product.
PRICE: And that natural product is resveratrol.
PALCA: You may have heard of resveratrol. It's a compound in red wine that was supposed to have all sorts of healthful properties. But wine doesn't have enough resveratrol to provide any real benefits. But Price and his colleagues were able to show that using concentrated resveratrol in a cream applied to the skin relieved pain in animals. Now, when something appears to work in animals, the next step is typically to do what's called a clinical trial testing it in people. But Price says they didn't do that.
PRICE: The reason we didn't do that is pretty simple. We couldn't raise the money to do it.
PALCA: Clinical trials are expensive. And Price didn't have to do a clinical trial so long as he didn't make any specific claims that resveratrol would ease pain.
PRICE: We just eventually decided that it was better to get this out there than to continue to try to raise the money and running the risk of never actually getting this into the hands of people that it can help.
PALCA: So Price decided to manufacture his cream and sell it on the Internet. It costs 19 bucks. Was that the right decision? Well, veteran pain researcher Jon Levine isn't bothered by the fact that there's no clinical trial showing the cream works. Levine is at the University of California, San Francisco.
JON LEVINE: If something is not harmful - and I think the chance that this could be harmful is incredibly small - then if this is not a financial burden for somebody and they wanted to try it, then I certainly would see no reason not to. And there certainly would be some scientific reason to think that it might help.
PALCA: For his part, Ted Price would still like to do a clinical trial to prove his pain cream works.
PRICE: Any physician listening that would like to do a clinical trial with topical resveratrol, I would be extraordinarily enthusiastic about doing that.
PALCA: In the meantime, you'll have to decide on your own if Price's cream is for you. Joe Palca, NPR News.
(SOUNDBITE OF MOON BOUNCE SONG, "DRUGS")
NPR transcripts are created on a rush deadline by Verb8tm, Inc., an NPR contractor, and produced using a proprietary transcription process developed with NPR. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR’s programming is the audio record.