Human Embryoids Can Now Be Mass-Produced : Shots - Health News Researchers hope large numbers of very primitive, embryo-like structures will lead to new insights into early human development and ways to prevent miscarriages and birth defects.
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Scientists Create A Device That Can Mass-Produce Human Embryoids

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Scientists Create A Device That Can Mass-Produce Human Embryoids

Scientists Create A Device That Can Mass-Produce Human Embryoids

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MARY LOUISE KELLY, HOST:

Scientists have found a way to produce large numbers of living entities that resemble very early human embryos. The step is being hailed as a big advance in the study of human development. It also raises questions about where to draw the line in manufacturing synthetic human life. NPR health correspondent Rob Stein has more.

ROB STEIN, BYLINE: Imagine lab dishes churning out microscopic clumps of human cells, balls of cells that look a lot like very early human embryos. That's what Jianping Fu is doing at the University of Michigan in Ann Arbor.

JIANPING FU: The embryonic-like structures we're generating in the lab, they are very similar to - they resemble a portion of the human embryo, the core of the early human embryo.

STEIN: They're made out of human stem cells. Fu isn't the first scientists to start coaxing stem cells into becoming embryoids, as some scientists call them. But Fu figured out how to make lots of them really fast.

FU: So this new system allow us to achieve a superior efficiency to generate this human embryo-like structures. Therefore, it's an exciting new milestone for this emerging field.

STEIN: Fu says he can generate hundreds of embryos in just a few days. But why? Why would anyone want to make lots of living things that look a lot like human embryos?

FU: So such human embryo-like structures have a lot of potential to open what we call the so-called black box of human development.

STEIN: That's the first few weeks after a sperm fertilizes an egg, when the embryo is hidden inside a woman's body. And scientists aren't allowed to study them in their labs for ethical reasons.

FU: During this period, many miscarriages can happen. And serious birth defects can form.

STEIN: So Fu hopes his embryoids will help scientists find new ways to prevent those problems by studying the earliest stages of embryonic development and do other things, like use these embryoids to test drugs to make sure they're safe for pregnant women to take.

FU: So such research can lead to a lot of good.

STEIN: Other scientists agree.

ALI BRIVANLOU: It's a major advance in the knowledge of human - early human development.

STEIN: Ali Brivanlou is an embryologist at the Rockefeller University in New York.

BRIVANLOU: And we're opening up windows to an aspect of development that we have never seen before. This knowledge is really the holy grail of human embryology.

STEIN: But this sort of thing is tricky. Fu's walking a really thin line here. Insoo Hyun is a bioethicist at Case Western Reserve University. He says Fu has done the right thing by making sure his synthetic embryos aren't getting too close to actual human embryos.

INSOO HYUN: The scene needs to be very careful not to model all aspects of the developing human embryo so that they can avoid the concern that this embryo model could one day become a baby if you put it in the womb.

STEIN: Because that would set off all kinds of alarm bells about mass producing human life and experimenting on human embryos. Fu says he gets it.

FU: I understand that there may be people sensitive. When you see that we can massively produce organized embryonic structures, people will be concerned. I understand that. Yeah, I guess we are pushing the boundary.

But I want to make 100% clear that we have no intention trying to generate a synthetic structure look like a complete human embryo. So we have zero intention to do that.

STEIN: But if someone took this technology and did try to go further, Daniel Sulmasy, a Georgetown University bioethicist, says that possibility conjures up some disturbing scenarios.

DANIEL SULMASY: That would be sort of like a very early sort of Frankenstein model - right? - taking different parts and stitching them together in order to try to create an organism. If somebody tried to do it, and it were even at the earliest stages of embryonic development and they tried to then let it develop further, that would be a problem.

STEIN: So the International Society for Stem Cell Research is planning to revise its guidelines for how far scientists should be allowed to go in creating human embryo models from human stem cells.

Rob Stein, NPR News.

(SOUNDBITE OF JONATHAN FITOUSSI AND CLEMENS HOURRIERE'S "LABYRINTHS")

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