Study Links PFC Exposure to Impaired Immune Function in Kids : Shots - Health News Researchers found that children whose blood contained high levels of chemicals used in nonstick coatings and stain-resistant fabrics were less responsive to vaccination. The finding suggests, but doesn't prove, that these chemicals may make some children more vulnerable to infectious diseases.

Common Chemicals Could Make Kids' Vaccines Less Effective

  • Download
  • <iframe src="" width="100%" height="290" frameborder="0" scrolling="no" title="NPR embedded audio player">
  • Transcript


A new study finds that chemicals known as PFCs can impair a child's immune system. PFCs are found in non-stick coatings, stain-resistant fabrics, food packaging and even some seafood. Their use is declining in the U.S.

But as NPR's Jon Hamilton reports, exposure to even relatively low levels seems to have an effect.

JON HAMILTON, BYLINE: In the past decade, scientists have become increasingly concerned about PFCs, which are known formally as perfluorinated compounds. Philippe Grandjean, who works at Harvard and the University of Southern Denmark, says one reason is that PFCs are just about impossible to avoid.

PHILIPPE GRANDJEAN: These compounds have been around for, like, 50 years. I mean, you can find them in polar bears and they are all over the environment.

HAMILTON: Also, PFCs tend to linger for years in the body and, in lab animals, they've been shown to suppress the immune system.

Grandjean wanted to know whether this was happening in children, so he led a team that studied nearly 600 kids in the Faroe Islands, which lie about halfway between Scotland and Iceland. The Faroese have levels of PFCs similar to those of U.S. residents. Grandjean figured that if the chemicals were having an effect, it would show up in the way the kids' bodies responded to vaccinations.

Normally, a vaccine causes the production of lots of antibodies to a specific germ, but Grandjean says that response was less pronounced in the children whose blood contained higher levels of PFCs.

GRANDJEAN: We found that, the higher the exposure, the less capable the kids were in terms of responding appropriately to the vaccine and some of the kids were more or less incapable.

HAMILTON: The study looked at the responses to vaccines for diphtheria and tetanus in children from five to seven years old. Grandjean says the result suggests these kids have a blunted response to other vaccines, as well, and perhaps bigger problems.

GRANDJEAN: Of course, we worry that something more serious is going on here, that the immune system is not really developing optimally.

HAMILTON: If so, children with higher levels of PFCs might be less able to fight off infectious diseases.

Alan Ducatman from West Virginia University has worked on something known as the C8 Health Project, which has been studying the health effects of one particular PFC in Ohio and West Virginia.

He says results from the new study are consistent with some of their own findings regarding PFCs and immune function.

ALAN DUCATMAN: PFCs have certainly undergone a transformation in our perspective on them over one decade.

HAMILTON: Ducatman says consumers in the U.S. have reason to be concerned, even though companies here have phased out some PFCs and some exposure levels have begun falling. Ducatman says PFCs are not the most frightening chemicals out there.

DUCATMAN: But they are also clearly problematic and something to think about and, to the degree that levels are going down in the United States, we should also acknowledge that they're not going down in other parts of the world and, in fact, there are places where they may even be going up.

HAMILTON: Grandjean says China is one country that appears to be using more PFCs these days and they are putting them in products that get sold in the U.S.

GRANDJEAN: We may just be importing products with the same compounds instead, so I don't think that we have solved the exposure problem yet and I think it needs international attention.

HAMILTON: It's getting some. Global treaties are just beginning to include language restricting the use of certain PFCs. The new study appears in the Journal of the American Medical Association.

Jon Hamilton, NPR News.

Copyright © 2012 NPR. All rights reserved. Visit our website terms of use and permissions pages at for further information.

NPR transcripts are created on a rush deadline by an NPR contractor. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR’s programming is the audio record.