A Little Acid Turns Mouse Blood Into Brain, Heart And Stem Cells : Shots - Health News Japanese scientists say they've figured out a fast, easy way to make the most powerful cells in the world: embryonic stem cells. The magic ingredient? Something akin to lemon juice. So far it's unknown whether the method would work with human cells or could be used for medical treatments.

A Little Acid Turns Mouse Blood Into Brain, Heart And Stem Cells

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Scientists are reporting what may be a big advance in stem cell research. Researchers believe they found a quicker, easier and less controversial way to make stem cells. NPR's Rob Stein reports the news is stirring excitement, surprise and questions in the scientific world.

ROB STEIN, BYLINE: Human embryos contain cells that have the ability to become almost any kind of tissue in the body. They're called stem cells, and the great hope is that someday, they could be used to cure lots of diseases. Charles Vacanti of the Brigham and Women's Hospital in Boston says that includes Alzheimer's, Parkinson's, diabetes.

CHARLES VACANTI: There are many, many diseases that you could potentially cure if you put in the proper cells in the proper location and they function normally.

STEIN: But human embryos have to be destroyed to get these cells, which makes them extremely controversial. So, scientists have been trying to find other ways to make stem cells, and they've been able to do that. They've tinkered with the genes of mature cells and got them to morph back into embryo-like cells. But those cells may have their own problems.

VACANTI: People have suggested that you are more prone to have - develop cancer. Is that true? Possibly.

STEIN: But Vacanti and his colleagues had another idea: Maybe they could make stem cells by mimicking what happens when the body naturally repairs itself.

VACANTI: You know, if you're walking down the street and you fall down and bruise your leg, you know, if you're punched in the eye - wherever you're injured - is that the mature cells are actually reverting back to a stem cell to now repair the injured tissue.

STEIN: So, Vacanti teamed up with some Japanese researchers to see if they could make mature cells turn back into stem cells in the laboratory. The scientists took cells from newborn mice and subjected them to the same kinds of stresses that occur in the body during an injury. For example, they exposed the cells to increased levels of acidity.

VACANTI: We found that if we injured them, almost to the point of dying, but not quite to the point of dying, the cells would revert back to a stem cell state.

STEIN: A stem cell state very much like embryonic stem cells. Then they showed they could use these cells to create virtually every kind of tissue in the body. They went even further. They used these cells to create complete mouse embryos.

VACANTI: It demonstrates that you have the ability to make perfect embryonic stem cells that can then turn into a perfect copy of your own cells.

STEIN: Other scientists were blown away by the research, which was described in two papers in this week's issue of the journal Nature.


STEIN: That's George Daley, a leading stem cell scientist at Harvard who was not involved in the research.

DALEY: I mean, I cannot remember reading a paper and feeling so amazed and perplexed at the same time. I mean, it's truly a startling result.

STEIN: It's perplexing, because it raises fundamental questions about how cells really work. Scientists had no idea that our bodies could turn back the clock on cells on their own.

DALEY: This is going to open up whole new ways of thinking about cellular alchemy.

STEIN: And it's startling because it seems to offer a way to make stem cells that's really easy and really fast.

DALEY: The potential is limitless.

STEIN: But Daley and others caution that there's still lots more research that needs to be done to confirm the findings and answer some big questions. Austin Smith is at the University of Cambridge.

AUSTIN SMITH: So, we need to know if this works with adult cells, and then we need to know if it works in human cells, if you're thinking it could be important for some medical purpose.

STEIN: Vacanti says he's already started experiments to see if this works with human cells the way it does with mice, and that he's already got some early results that look very promising. Rob Stein, NPR News.

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