Scientists Give Genetically Modified Organisms A Safety Switch : Shots - Health News By making E. coli dependent on an artificial amino acid, scientists hope to show that engineered organisms can be safer and more useful for industrial processes like drug production.

Scientists Give Genetically Modified Organisms A Safety Switch

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Genetic engineering is used for everything from crops like corn and cotton to designer drugs, and the technology is getting more sophisticated all the time. Scientists are even changing the language of genes by rewriting the genetic code. Researchers at Harvard and Yale are starting to use these tools to build safety features into designer organisms. Two studies in the journal Nature report a major step forward in that effort, as NPR's Richard Harris reports.

RICHARD HARRIS, BYLINE: First, a two sentence refresher on some basic biology. The enzymes and other proteins in our bodies are all built from building blocks called amino acids. There are usually just 20 amino acids in nature, but George Church at Harvard has created a bacterium that requires an additional amino acid - one made in the lab and not found in nature.

GEORGE CHURCH: So this really makes it a completely new branch of life.

HARRIS: These modified E. coli bacteria essentially speak a different genetic language from all other life on Earth. That means they can't easily swap genes which bacteria often due to pick up or get rid of traits. And it also means that these modified bacteria must be fed this synthetic amino acid.

CHURCH: It will die as soon as you remove that essential nutrient.

HARRIS: It's a radical reengineering of life, but Church says this actually makes these synthetic life forms safer because if they escape into the wild they'll die. And it also makes them less vulnerable to being infected by viruses. Yes, bacteria get infections, too. That's a selling point for the biotech industry which uses bacteria to make things like drugs. Those operations are vulnerable to viral infections.

CHURCH: If you get your factory contaminated, it can be hard to clean out for year.

HARRIS: So Church is hoping that industry will want to start using these highly engineered bacteria not for the safety considerations as much as to help them avoid contamination.

CHURCH: We get two or three things for the price of one.

HARRIS: How do you know it won't mutate and be able to basically shake off these traits that you've added?

CHURCH: Well, we anticipated it would be able to mutate and shake off the traits if we just did one.

HARRIS: With one modified gene, Church found that there's a one-in-a-million chance that the bacteria could once again live in the wild without the synthetic amino acid. But by modifying multiple genes, the odds of that drop sharply.

CHURCH: So the current strains are at least one-in-a-trillion, if not, better than that.

HARRIS: Farren Isaacs who left Church's lab at Harvard to start his own at Yale has kept pace with his former boss. He too has built some safety features into E. coli, and he says it's possible to use this approach for all sorts of other organisms - for example, bacteria that you spray on an oil spill to help clean it up or bacteria that produce probiotics for human consumption.

FARREN ISAACS: This also sets the stage for opening up new types of applications going forward.

HARRIS: It's harder to think about how this technology could be used in agriculture. If you build this into genetically engineered crops, you'd need to feed them the artificial amino acid that they'd require from crop dusters or something like that. And the artificial amino acid would be part of the grain, so you'd need to prove that it's safe to eat. Jennifer Kuzma is codirector of the Genetic Engineering and Society Center at North Carolina State.

JENNIFER KUZMA: I think it's commendable that they're starting to design safety into genetically modified organisms, however, I really don't think it's going to affect the public perception that much or the way we have to deal with the uncertainty anyway. You may reduce the chance of spread, but you cannot eliminate it completely.

HARRIS: Science doesn't offer absolutes, but this technology is evolving quickly, and George Church says it's important to engineer in safety features as they go. Richard Harris, NPR News.

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