Why A Vaccine That Works Only A Third Of The Time Is Still A Good Deal : Goats and Soda The first vaccine against a parasite — one that causes malaria — was recommended for approval. It's not as effective as researchers had hoped, but they still think it could make a big difference.

Why A Vaccine That Works Only A Third Of The Time Is Still A Good Deal

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The European Medicines Agency has recommended approval of the first vaccine against malaria. It's a key step in getting a malaria vaccine to market in the developing world. We should note that it was developed with funding from the Gates Foundation. The foundation is also one of NPR's financial supporters. This new vaccine is a milestone achievement in the fight against malaria. But as NPR's Jason Beaubien reports, it has its flaws.

JASON BEAUBIEN, BYLINE: The malaria vaccine known as RTS,S has been under development for three decades. This green light from the European Medicines Agency means it's now on the verge of being marketed commercially as one more tool against malaria. Unfortunately, RTS,S is not nearly as effective as many people had hoped. But William Moss, a professor of epidemiology at Johns Hopkins, says it's still important.

WILLIAM MOSS: I think this could be a game changer in specific settings.

BEAUBIEN: Unlike vaccines for other diseases that are 80-90, even 99 percent effective, this new vaccine has an efficacy rate between 26 and 36 percent. In a study of 15,000 infants and young children in Africa, RTS,S only showed a lasting benefit against severe malaria in kids who were injected with four doses of the vaccine over the course of 18 months. And Moss at Johns Hopkins says making sure children get all four doses on schedule could be difficult.

MOSS: The challenge will be actually delivering this vaccine.

BEAUBIEN: The problem is that places that need this vaccine the most - the countries with the highest rates of malaria - tend to be the places with the most dysfunctional health systems.

MOSS: Currently, most countries throughout sub-Saharan Africa where the malaria burden is greatest do not have a mechanism for delivering three or four doses of a vaccine in the second year of life.

BEAUBIEN: So you have a vaccine that's less effective than just about everybody'd hoped. The timing of when kids have to get these four shots is out of sync with other vaccines. And while GlaxoSmithKline has pledged to sell it at manufacturing costs plus 5 percent, it's still going to be an additional financial burden for already impoverished nations.

Despite its drawbacks, RTS,S could become an important public health weapon mainly because rates of malaria in some places are astronomically high. There are nearly 200 million cases of malaria and half a million deaths from the disease each year mainly in Africa. Moncef Slaoui, the head of vaccines at GlaxoSmithKline, has worked on this project ever since he joined the company 27 years ago. He says one of the main accomplishments here is that RTS,S is the first human vaccine to work against a parasite.

MONCEF SLAOUI: Parasites are extraordinarily complex organisms. In this instance, this parasite has three different forms of life that are totally disconnected.

BEAUBIEN: So the vaccine has to be able to protect someone from all three stages the parasite's life. Stanley Plotkin, a professor emeritus at the University of Pennsylvania and one of the editors of the medical reference book "Vaccines," is disappointed with RTS,S's efficacy rate. But he says getting a parasite vaccine to market is a major step forward in immunology. Plotkin adds that a vaccine could help provide herd immunity against malaria. By driving down the number of infections, there will be fewer parasites available to spread and thus, hopefully, fewer cases of disease.

STANLEY PLOTKIN: One can hope that employment of a vaccine, even though its primary efficacy will be low, will have a public health effect that will be larger than one would expect from the vaccine itself.

BEAUBIEN: Even if RTS,S is rolled out on a large scale, the expectation among researchers is that all the other current measures against malaria - bed nets, mosquito control programs, things like that - will have to continue at the same time if significant progress is going to be made against this tropical disease. Jason Beaubien, NPR News.

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