Monkey Clones Made By Somatic Cell Nuclear Transfer : Shots - Health News A team of researchers has produced two macaque monkey clones using a technique called somatic cell nuclear transfer. It's a first for primates. The advance could hasten research into human diseases.
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Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep

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Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep

Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep

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MARY LOUISE KELLY, HOST:

Chinese researchers have finally done something scientists have been trying to do for decades - use the same technique that cloned Dolly the sheep to clone a primate. The advance could be a big boon to medical research, and NPR health correspondent Rob Stein has details.

ROB STEIN, BYLINE: Ever since Dolly the sheep was cloned, scientists have been trying to use the same technique to clone other species, and it's worked. They've cloned cows, dogs, pigs, cats and a long list of other species, but no one has ever been able to clone a chimp or an ape or any other primates. Some started to think it just wasn't possible, until now.

MU-MING POO: We're excited. Lot of people are excited.

STEIN: That's Mu-ming Poo at the Chinese Academy of Sciences. We talked on Skype.

POO: This is really, I think, a breakthrough for biomedicine.

STEIN: Two baby macaque monkey clones were born in Shanghai six and eight weeks ago. Their names are Zhong Zhong and Hua Hua, after the Chinese word Zhonghua, which means Chinese people.

POO: They are lively. They are walking, jumping, playing around like all newborn baby monkeys.

STEIN: Poo's team finally did it by pulling the DNA out of cells from fetal monkeys, putting the genes into monkey eggs and then tricking the eggs into developing into embryos with just the right chemical signals.

POO: The trick is that we choose the right chemicals to turn on these genes we transfer into the egg, OK? So that's what we did different. I think that's the key.

STEIN: They then transplanted the cloned monkey embryos into surrogate female monkeys. But why? Why clone monkeys? Well, because primates like monkeys are our closest relatives, so scientists could use cloned monkeys to study a long list of terrible diseases and hopefully find new cures.

POO: We need to have genetically identical monkeys that's cloned for study many human diseases, especially brain diseases.

STEIN: Brain diseases like Alzheimer's, Parkinson's, Huntington's, maybe even autism.

DIETER EGLI: I think it's a very exciting landmark. It's a major advance.

STEIN: That's Dieter Egli, a biologist at Columbia.

EGLI: These monkeys should be useful for medical research. It should be possible to make models of human disease in those monkeys, and study those and then attempt to cure it.

STEIN: But this step is also causing some concerns.

INSOO HYUN: This is a case of monkey see, monkey do.

STEIN: Insoo Hyun is a bioethicist at Case Western Reserve University.

HYUN: People may wonder, are human beings next? People have always been worried about the possibility of human cloning, and this is just a - yet another step in that direction. So there is certainly a concern about, how close are we to the reality of human cloning?

STEIN: Because human biology is so similar to monkeys. But Hyun and others say it would be highly unethical to even try, for lots of reasons. First of all, it's not safe. A lot of the cloned monkey embryos the Chinese created died in the womb or soon after birth.

HYUN: So safety of the resulting child is a major concern.

STEIN: But even if it was safe, many say there are big reasons never to try. George Daley is the dean of the Harvard Medical School.

GEORGE DALEY: Cloning one individual in the image of another really sort of demeans the significance of us as individuals. There's a certain sort of gut sense that it violates sort of a natural norms.

STEIN: But Daley worries that some rogue scientist somewhere might try, even though there are laws against human cloning in many countries.

DALEY: We live in such a celebrity-driven world that there are unscrupulous practitioners who might try this.

STEIN: The Chinese scientists acknowledged that any new technology can be abused but stressed they have no interest in ever trying to clone a person.

POO: Technically speaking, one can clone human, but we are not going to do it. There is absolutely no plan to do anything on a human.

STEIN: They just want to find new ways to cure diseases, so they already have other monkeys pregnant with cloned embryos in the hopes they'll give birth to more cloned monkeys soon. Rob Stein, NPR News.

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